WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

ON THE SYNTHESIS AND CHARACTERIZATION OF METHYL ESTER OF 3-AMINO-4- HYDROXY BENZOIC ACID

*Pralay A. Barhewar, Nagmani W. Pendor, Manoj S. Charde and Rita D. Chakole

Abstract

The main objective of medicinal chemistry is to synthesize the methyl ester of 3-amino-4- hydroxy benzoic acid which has a topical as well as local anaesthetic. This anaesthetic have been reported to synthesized by 3-nitro toluene and 4-hydroxy benzoic acid followed by esterification. Here, we reported the synthesis by para hydroxy methyl benzoate. Anaesthetics are a diverse group of drugs that are used for relieving from pain. The administration of anaesthetics is necessary to inhibit the individuals pain pathway and for easiest and safety local surgical procedures. This article describes the easiest, safest, economical way of synthesis of orthocaine. Orthocaine is the methyl ester of 3-amino-4- hydroxy benzoic acid. The synthesis of orthocaine was carried out by nitration followed by reduction of 4-hydroxy methyl benzoate. The reduction procedure are optimized by using various reductive agents. The synthesized compound was further investigated by Thin Layer Chromatography, spectroscopic techniques such as MASS, NMR, ATR-IR and physical constant.

Keywords: Orthocaine, Thin layer chromatography, spectroscopic technique, physical constant, 4-hydroxy methyl benzoate.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More