Abstract

A PHARMACEUTICAL AND PHARMACOGNOSTICAL STUDY OF TRISHNA NIGRAHANA MAHAKASHAYA GHANAVATI IN THE MANAGEMENT OF KLEDA W.S.R. TO MADHUMEHA (TYPE 2 DIABETES)

Priya Gupta*, A. S. Baghel and Harisha C. R.

Abstract

Introduction: Entire universe made up of five basic elements called Panchamahabhuta. Ayurveda emphasize the role of water (Jala Mahabhuta) in body as a most important element of body as well as treatment point of view. Ayurveda consider thirst as not only natural urge but also uses it as a treatment modality in some of the diseases. Trishna Nigrahana Mahakashaya (important decoctives for thirstrestraining) is such preparation which helps to get control over water consumption. Material and Method: This study has been conducted to evaluate the role of Trishna Nigrahana Mahakashaya Ghanvati for Kleda (body moisture) management. The drug is going to use in the form of Ghanvati and subjected to Pharmacognostical and physicochemical evaluation. Observation and Results: The Pharmacognostical results showed that the presence of Chollenchyma cells of Guduchi, Starch grains of Shunti, Brown cantant of Musta, Prismatic crystal of Dhanyvasa, Starch grains of Patola, Fibres of Parpataki, Fibres of Patola, Fibres of Guduchi, Silica deposition of Musta, Clustar crystal of Dhanyvayasa, Brown cantant of Chandana, Brown cantant of Kirattikta, Starchgrain of Musta, Trichome of Kirattkita, Epicarp cells of Dhanayak, Starch grain and crystal of Parpataki, Lignified collenchymas cells of Guduchi, Lignified fibres of Chandana, Stiated fibres of Dhanyak, Annular vessels of Musta, Bordered pitted vessels of Guduchi, Fragment of spiral vessel of Patola, Oil Globule of Dhanyaka, Stone cells of Chandana, Trichome of Patola. Physicochemical Parameters of the tablet like Uniformity (497.6 mg), Disintegration time (20 min), Hardness (2.2kg/cm2), Ash value (8.18%) and Loss on Drying (10.28%) were all found to be within the normal range. The water soluble extractive and methanol soluble extractive values were found to be 31.12 % w/w and 21.36 % w/w respectively.

Keywords: Trishna Nigrahana Mahakashaya, Pharmacognosy, Physicochemical analysis, Kleda Management.