Abstract

DEVELOPMENT OF NANOMATERIAL BASED TOPICAL DRUG DELIVERY SYSTEM FOR DIABETIC RETINOPATHY

S. Chandra*, A. Sheikalisha*, B. Nandhini, R. Suresh and B. Kavibharathi Muhammed Fazal K.

Abstract

The rationale of the research was to formulate and evaluate the triamcinolone loaded Nanostructured lipid carriers delivered through periocular sub conjunctival route for the treatment of diabetic retinopathy. The Nanostructured lipid carriers were prepared by high pressure homogenization method. FTIR was carried out to identify their functional groups and DSC was carried out to determine their melting point. The particle size, poly dispersity index and zeta potential obtained for triamcinolone loaded with NLC was found to be 203.4, 0.204 and – 33.1mV respectively. The pH of the formulation was found to be 7.2. The entrapment efficiency of triamcinolone Nanostructured lipid carriers was 69.78% which, indicates most of the drug was encapsulated. The scanning electron microscopy and X-Ray diffraction studies was done to know the surface morphology and crystallinity of the Nano lipid carrier. Thedrug release from the Nanostructured lipid carrier shows greater release till 15 h. The stability studies were done for the formulation and the formulations loaded with triamcinolone was investigated at 25°C and few formulations leads in phase separation and unstable. Formulations TRC-NLC F2 and TRC-NLC F3 were found to be stable. Hence it can be concluded that triamcinolone loaded Nano lipid carrier showed sustained release activity and it might be suitable for the treatment of diabetic retinopathy.

Keywords: Triamcinolone, TRC-NLC F2, TRC-NLC F3.