Abstract

FORMULATION AND EVALUATION OF TOPIRAMATE FAST DISSOLVING ORAL FILMS

Muggu Sankara Bhavani*, B. Divya Kanthi, B. Jyothi, G. Sailaja and G. Naga Mani

Abstract

The purpose of this research work was to formulate a fast dissolving film of Topiramate for the treatment of seizures. The fast dissolving films of Topiramate were prepared by solvent casting technique using film forming polymer HPMC 5, 15 and 50 cps and Propylene glycol as a plasticizer. From the preliminary physical observation of these prepared films the best were selected for incorporation of Topiramate. The electron microscopy showed that the films are clear, colorless with smooth surface and little pores, without any scratches on the films. All the films prepared were evaluated for Physical appearance and surface texture, weight uniformity of films, thickness of the films, folding endurance, surface pH, drug content uniformity and in-vitro disintegration time of films all the results were found to be satisfactory. Among all the film formulation F2 were found to be promising and showed a disintegration time of 46 sec, respectively and 99.89% of drug released in 6 min. Based on the above results it can be concluded that the fast dissolving oral film of Topiramate may produce the rapid action thereby enhance the absorption by avoiding the first pass effect.

Keywords: Fast dissolving film, Topiramate, Hydroxypropyl methylcellulose, Polyvinyl alcohol, Citric acid, Solvent casting.