Abstract

TRANSDERMAL ORGANOGEL FOR NSAIDS CONTAINING DRUG IBUPROFEN

Aishwarya Ratnakar*, Arun Patel, Shailendra Patel and Neelesh Dwivedi

Abstract

Topical administration via the dermal route can bypass disadvantages of the oral route. Therefore, transdermal drug delivery has been considered to be an ideal route for administration of NSAIDs. Drugs can be delivered across the skin to have an effect on the tissues adjacent to the site of application or to have an effect after distribution through the circulatory system (systemic delivery). While there are many advantages to delivering drugs through the skin the barrier properties of the skin provide a significant challenge. By understanding the mechanisms by which compounds cross the skin it will be possible to devise means for improving drug delivery.

Keywords: Ibuprofen, Pluronic F-127, Potassium sorbate.