Abstract

PREPARATION AND IN-VITRO EVALUATION OF CYCLODEXTRIN NANOSPONGE OF POORLY WATER SOLUBLE DRUG VALDECOXIB

Himesh Shrivas*, Sanjay K. Jain, Dr. Anil Kumar Chaurasiya, Dr. Vijay Nigam and Brijendra Ahirwar

Abstract

Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures in which solid nanoparticles are entrapped within nanosized cavities. The aim of this study was the development of Valdecoxib loaded β-cyclodextrin (β–CD) based nanosponges for improving dissolution rate and bioavailability and bitter test masking. Nanosponge were prepared by reacting β-CD with the cross-linker carbonyldiimidazole at different ratios. On the basis of Percentage yield, Solubilization efficiency and Entrapment efficiency BN6 formulation is selected for further study. BN6 formulation showed a significant improvement in the rate of release. This improvement may be due to the increase in solubility and wettability caused by complex formation and processes. The particle size of BN6 formulation was found to be 322.5 nm with low Polydispersity indices. Zeta potential is sufficiently high to obtain a stable colloidal nanosponge.

Keywords: Valdecoxib, Nanosponge, Cyclodextrin, Cross linker, Entrapment efficiency, Dissolution rate.