Abstract

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF FLOATING IN-SITU GELLING SYSTEM FOR LISINOPRIL DIHYDRATE

Raosaheb S. Shendge, *Ashwini A. Jamdhade, Vishal V. Pande and Rupali N. Kadam

Abstract

The aim of this study was to develop a novel gastro retentive floating in-situ gelling system for controlled delivery of lisinopril dihydrate for treatment of hypertension. Gellan gum based lisinopril dihydrate floating in situ gelling systems was prepared by dissolving varying concentrations of gellan gum in de-ionized water containing sodium citrate and calcium chloride. This mixture was then heated to 900C and cooled to 400C followed by addition of mixture of lisinopril dihydrate coated with 2% solution of TPP, than CaCO2 was added to form a uniform dispersion. The formulation variables like gellan gum and calcium carbonate significantly affected the in-vitro drug release, viscosity, in-vitro buoyancy and floating lag time. Lisinopril dehydrate floating in-situ gel (LFIG) showed significant anti-hypertensive effect. The results further showed that the prepared LFIG has feasibility of forming rigid gels in the gastric environment and gives anti-hypertensive effect from gastro- intestinal tract. Lisinopril dihydrate floating in-situ gel was found more effective than the lisinopril dehydrate suspension because of the prolonged gastro-intestinal residence time of the formulation.

Keywords: Gastro Retentive Drug Delivery System, In-situ gel, lisinopril dehydrate, Hypertension, Floating drug delivery system.