Abstract

SYNTHESIS AND ANTIBACTERIAL STUDY OF THIADIAZOLE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

Krishnakant T. Waghmode*, Vishal Jadhav and Bandoba T. Nikam

Abstract

Orthophenylene diamine was reacted with a dicarboxylic acid in acidic condition to give benzimidazole substituted carboxylic acid (3). The reaction of benzimidazole substituted carboxylic acid with thiosemicarbazide in presence of phosphorous oxychloride yielded benzimidazole substituted-2-amino thiadiazole (5). In the next step benzimidazole substituted amino benzothiazole was reacted with glyoxal to get substituted imino aldehyde (7). Imino aldehyde was reacted with different substituted aromatic amines to afford final product (9). Substituted derivatives of final product (9a-i) were synthesized in good to excellent yield. Synthesized compounds were characterized by using IR, NMR and Mass Spectroscopy. Further these compounds were subjected for their biological evaluation by studying their antibacterial activities against Staphylococcus Aureus (S. Aureus) and Escherichia coli (E. Coli) bacteria.

Keywords: Benzimidazole, benzothiazole, o-Phenylenediamine, Antibacterial activity.