Abstract

ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF HYDROALCOHOLIC EXTRACT OF FICUS MICROCARPA L. LEAVES IN EXPERIMENTAL ANIMALS

Sanjaya Kumar Y. R.*, Sudesh Gaidhani N., Sudheesh P. S. and Sudhakar D.

Abstract

Hydroalcoholic extract of Ficus microcarpa was screened for analgesic and anti-inflammatory activities in experimental animals. The test extract was found to be safe up to 2000 mg/ kg body weight during acute toxicity study. Hydroalcoholic extract of the test drug at doses of 250 mg and 500 mg per kg body weight showed significant analgesic activity through various models of nociception in Sprague Dawley rats and Swiss mice. The test extract was also found to possess significant anti-inflammatory activity as evidenced by carrageenan and formaldehyde hind paw oedema methods in Sprague Dawley rats.

Keywords: Ficus microcarpa, leaves, hydroalcoholic extract, analgesic, anti-inflammatory.