Abstract

ANTI-ANXIETY ACTIVITY OF AEGLE MARMELOS FRUIT EXTRACTS IN MICE

Maninder Kaur*, Abhishek, Ajeet Pal Singh and Amar Pal Singh

Abstract

Anxiety is one of the most common mental disorders, characterized by changes in mood, behavior, somatic function, and cognition. Benzodiazepines and SSRIs are most commonly employed drugs for the treatment of anxiety and provided various side effects. Drugs obtained from natural sources are known to cause fewer side effects compared to synthetic drugs despite of same ability to cure disease. Aegle marmelos is an ayurvedic medicinal tree belongs to family Rutaceae. It is commonly known as apple tree, stone apple tree found all over India. Aqueous and Ethanolic fruit extracts of Aegle marmelos used to evaluate Anti-Anxiety activity. These extracts administered orally in two different doses 100 mg/kg and 200 mg/kg as compare to dose of Standard drug (diazepam) 1 mg/kg. Plasma Corticosterone Level was also estimated by collected blood from tail vein after behavioral parameters. The results of our study demonstrated that the ethanolic and aqueous extracts of Aegle marmelos fruit has significant anxiolytic activity in LDM and HBT models of anxiety and also shown significant results in biochemical estimation.

Keywords: Aegle marmelos, Anti-Anxiety, Corticosterone levels, Light dark model (LDM) and Hole board test (HBT).