Abstract

CYCLOPHILIN A: A PERIODONTAL INTRIGUE

Suchetha Aghanashini, Swati George*, Apoorva Sokke Mallikarjunapa, Sapna N., Darshan B. Mundinamane, Divya Bhat

Abstract

Cyclophilins (CyPs) are ubiquitous, highly conserved proteins in humans. Cyclophilin A (CyPA) has been found to be a potent chemoattractant, which causes the recruitment of inflammatory cells to the local site of inflammation and thereby contributes to the pathogenesis of periodontal diseases. It has been studied that CyPA is secreted under various conditions such as oxidative stress, hypoxia, and certain infections and hence also functions in different signaling pathways by inducing inflammation via chemotaxis. In this review we intend to widen the horizon on our knowledge of cyclophilin A and its periodontal implications which still remain a mystery.

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