Abstract

POLYMERIC MICELLES: A NOVEL APPROACH TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUGS

Renu Tehlan* and Akshay Dahiya

Abstract

Almost 70% of synthetic substances are generally insoluble in water and in natural media and 40% of drugs with immediate – release and delivered orally, which are already marketed are found to be insoluble in water. After so many researches and advancements pharmaceutical industry has developed lots of novel ways to deliver drugs at different sites in body. Polymeric micelles are one of the novel approaches which has so many advantages while using as drug delivery method because of their biocompatibility, non-toxicity, nano-size, morphology, shell arrangement, stability. In this review we are going to study about how polymeric micelles are being used in oral drug delivery and in oncology by enhancing the solubility of water insoluble drugs also different methods of preparation of these micelles.

Keywords: Polymeric micelles, novel drug delivery, solubility enhancement, biocompatibility.