Abstract

COMPREHENSIVE REVIEW ON OSMOTIC DRUG DELIVERY SYSTEM

Jayendrakumar Patel*, Shalin Parikh and Shwetaben Patel

Abstract

Uncontrolled immediate drug release may sometimes cause local gastro intestinal or systemic toxicity, require frequent administration due to shorter half-life. Further, the rate and extent of absorption of drug from conventional dosage forms may vary greatly depending on factors such as presence of excipients, physicochemical properties of the drug, various physiological factors such as presence or absence of food, pH of gastro intestinal tract, gastro intestinal motility and so on. Scientist continuous efforts lead to development of new drug delivery system (NDDS) and currently it is essential area for drug research and development. The reason is the low cost of development and shorter time required to launch the NDDS compared to the new chemical molecule development. Through the NDDS, the existing drug molecule can gain a 'new life,' thus, increasing its market value, competitiveness, and patent life. Among the various NDDS available in the market, oral controlling (CR) systems hold the largest market share due to their obvious benefits for easier management and better patient compliance. The critical milestone in the oral NDDS development exist when the Osmotic drug delivery system (ODDS) was discovered, a new and highly versatile system, because drug release from these systems is independent of pH and other body parameters on a large scale and it is possible to quantify the release characteristics by improving drug properties and system. This review paper highlight the fabrication of ODDS, various novel osmotic technology, various factor contributing impact on drug release from ODDS, status of currently marketed as well as under development product based on ODDS.

Keywords: Osmotic Drug Delivery System, Osmosis, controlled release, osmotic pressure, novel drug delivery system.