Abstract

A BRIEF REVIEW ON BUCCAL DRUG DELIVERY SYSTEM: ADVANTAGES, LIMITATIONS, AND IMPACT ON HEALTHCARE SYSTEM

Mohit and Md. Sadique Hussain*

Abstract

Delivery of pharmaceutical formulations is approaching a revolutionary change where rising numbers of new drug delivery technologies are being used and are active therapeutically. The discovery and development of medical formulations is presently concentrated on the improvement of therapeutic drugs to be aimed at the targeted location or place to reduce total dissemination in the host. For the administration of the desired drug, buccal area of an oral cavity is desirable aim to resolve the limitation of conventional drug administration. Problems involving the presystemic metabolism and drug depletion in digestive tract can be prevented by mouth administration of the drug. Buccal drug delivery system is a novel method of drug delivering system which have various benefits involving oral administration. The duration of placement of the pharmaceutical formulations at the recommended site could be extended. The structures are in direct contact with both the absorbing surface and the mucus membrane thus enhance the medicinal effects of administered medicine. Besides having many advantages, buccal drug delivery system has few disadvantages such as buccal supply are comparatively limited areas and considerable medication loss could be cause by salivary movement and swallowing. Moreover, in future, the field of oral drug distribution is the need for secure and convenient buccal permeation absorption boosters.

Keywords: Novel drug delivery, Buccal drug delivery, Improved efficacy, Oral delivery, Targeted location.