Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES: A REVIEW

Anuja A. Malgunde*, Apeksha V. Masal, Thorat Sarika S., Sukanya P. Paricharak, Pallavi G. Dhavare

Abstract

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Bioavailability is defined as the rate and extent/amount of absorption of unchanged drug from its dosage form. A drug with poor bioavailability is one with poor aqueous solubility, slow dissolution rate in biological fluids, poor stability of dissolved drug at physiological pH, poor permeation through bio membrane and extensive pre-systemic metabolism. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development.

Keywords: Solubility, Bioavailability, enhancement techniques.