Abstract

SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG BY SELF EMULSIFYING DRUG DELIVERY SYSTEM: COMPREHENSIVE REVIEW

Abdul Halim*, Keshav Jindal and Mohammad Tarique

Abstract

The oral route is still the favoured route of medication administration in many disorders, and it is still the first approach explored in the production of new dosage types. Low and intermittent bioavailability is the biggest issue in oral drug formulations, primarily due to low aqueous solubility. This may contribute to high inter-subject heterogeneity, loss of proportionality of the dosage, and therapeutic insufficiency. 40 per cent of active compounds are known to be poorly water soluble. Self-emulsifying drug delivery systems (SEDDS) are an essential method for overcoming the low bioavailability of poorly soluble products. Hydrophobic medications may often be dissolved in SEDDS, enabling them to be encapsulated as unit dosage types for peroral administration. This article explores the formulation techniques for SEDDS, the methods for evaluating the emulsification effectiveness, and the functional effects of using SEDDS to improve the bioavailability of drugs in the gastro-intestinal tract.

Keywords: Self Emulsifying drug delivery, SEDDS, Bioavailability, Composition, and Future Prospective.