Abstract

FORMULATION AND EVALUATION OF ASPIRIN LOZENGES

Jaydeep S. Chauhan*, Dhara K. Patel, Anita N. Makwana, Sonal N. Bhaliya, Sazia S. Billamwala, Dr. Jigar Vyas and Dr. U. M. Upadhyay

Abstract

The word “Lozenge” is derived from French word “Lozenge”, which means a diamond shaped geometry having four equal sides. Lozenges are solid preparations that contain one or more medicaments, usually in a flavored, sweetened base, and are intended to dissolve slowly in the mouth. In short lozenge is a small medicated candy intended to be dissolved slowly in the mouth to lubricate and soothe irritated tissues of throat. Patient compliance is one of the important aspect for administration of drug especially those which are bitter in taste. For patient compliance attractive taste masking formulation are the needs of hour. In the present study aspirin sweetened tablet lozenges were designed for the effective treatment of tooth ache. which is used to reduce fever and relieve mild to moderate pain from conditions such as common cold, and headaches, muscle aches, tooth ache, cough relief to reduce throat pain. The main interest was for the development of new dosage forms and the effect of different concentration on the in-vitro release. At the outset, estimation of drug by UV spectrophotometer was carried out. The possible interaction between the drug and excipient can be studied by FTIR spectroscopy. Lozenges could be successfully prepared by fusion method using sucrose, liquid glucose, aspartame, sucrose, dextrose, flavor and color. In-vitro release rate studies showed that the drug release for lozenges was maximum in formulation F1. And at end the drug content is compared with the marketed 75mg tablet which was found to be obtained in F1.

Keywords: Lozenge, Patient compliance, aspirin, liquid glucose, Fusion method.