Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF LIPOSOMAL GEL FOR TREATMENT OF FUNGAL INFECTION

Sandeep Kumar Maharaj*, Rahul Sharma and Dr. Jagdish Chandra Rathi

Abstract

Econazole nitrate (ECZ) is one of the triazole antifungal drugs with poor aqueous solubility and dissolution rate; there is a need for enhancement of solubility. Liposomal gel have emerged as one of the most interesting topical delivery system as it has dual control release system i.e. gel and emulsion. One side the topical applications of the drug offers the potential advantages of delivering the drug directly to the site of action and secondly delivering the drug for extended period of time at the effected site. The major objective behind this formulation was enhancing the topical delivery of hydrophobic drug by formulating Econazole nitrate liposomes. % Entrapment efficiency of optimized liposomes formulation (F-4) was found 73.32±0.58%. Optimized formulation of liposome further incorporated into gel base and evaluated for Viscosity, pH, Drug content, Extrudability and Spreadibility. Viscosity was found 2562±15, 2420±36 and 2345±74 LG-1, LG-2, LG-3 respectively, as the concentration of Carbopol increase the viscosity of formulation decreases. pH of prepared formulation was found 6.9±0.2, 7.0±0.1 and 6.8±0.2 for LG-1, LG-2, LG-3 respectively. The maximum drug content was found in formulation LG-2 (99.45±0.11) select as optimized formulation. The in vitro drug release study of prepared formulation LG-2, was found 98.78% after 12 hrs. Prepared gel containing Econazole loaded liposomal formulation was optimized and successfully formulated in the form gel can be use for topical preparation for anti-Fungal effect.

Keywords: Econazole nitrate, Liposomal gel, Evaluation, Antifungal effect.