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Abstract

A STUDY ON THE EFFECT OF PROBIOTIC CURD SUPPLEMENTATION ON HIV (PLWH) UNDERGOING ANTI-RETROVIRAL THERAPY (ART)

Amruth Rao P.*, Shiva Prakash M., Madhavi G., Sree Vennela Rao P., Khaleel Pasha MD, Srinivas V. and Hemalatha R.

Abstract

Background: Human Immunodeficiency Virus (HIV) infection results in gastro-intestinal damage, microbial translocation and immune activation which are associated with decreasing CD4 cell count and persistent abdominal distress. According to some research studies, probiotic food supplementation has been demonstrated to have promising results in improving the immune status i.e. CD4 cell profile in HIV subjects. Methods: In present study, about 100 patients (Males and Females) with an age range of 20-50 years, were identified for HIV Anti Retroviral Treatment(ART) and supplemented with indigenously prepared Probiotic curd (Indian dahi). The probiotic curd contained the blend of Lactobacillus bulgaricus, Streptococcus thermophilus and Bifidobacterium bifidum) daily for three months (3) along with their regular diet (noon meals). Their height, weight and Body Mass Index (BMI), Mid Upper Arm Circumference (MUAC) and Skin folds were recorded both at the baseline and after three months (90 days) i.e. before and after supplementation. Simultaneously blood samples were collected for CD4 cell counts, serum Adenosine deaminase (ADA) and total cholesterol (TC) levels for analysis. These patients were taking regularly Anti retroviral therapy (ART) at Osmania General Hospital, Hyderabad. Results: It was observed that all the anthropometric parameters were found to be significally increased. Further, the results showed that there was 0.08 log increase in the CD4 cell counts with an average 5 point decrease in the supplementation HIV subjects under study. However, there was decrease in cholesterol levels which was significant at 5% level i.e. the mean values decreased from 185 to 158 mg/ml. Similarly decrease was observed in the ADA levels showing the reversion back from abnormal to normal in these subjects after supplementation. Conclusion: The present study showed that the Probiotic curd (Indian dahi) prepared indigenously for supplementation was found to be effective as there was an improvement in the anthropometric parameters along with an enhancement of CD4 cell counts and decrease in cholesterol and ADA and in these subjects. Therefore, these observations suggest that inclusion of probiotic curd in the daily diet of HIV patients can have enormous improvement in their nutritional status. However, there is a need to conduct further studies at a larger level on the supplementation of probiotic based food products suitable to HIV subjects.

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