Abstract

FORMULATION AND EVALUATION OF PROLIPOSOMAL GELS OF NAPROXEN USING VARIOUS GRADES OF HPMC POLYMERS

Kukkamudi Pallavi*

Abstract

The development of in situ gel systems has received considerable attention over the past few years. In situ gel forming drug delivery systems are principle, capable of releasing drug in a sustained manner maintaining relatively constant plasma profiles. Naproxen is classified as a nonsteroidal anti-inflammatory drug (NSAID) Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Preparation of gels using appropriate amounts of excipients to obtain stable gel formulation for anti-arthritic drugs. Variables such as amount of phospholipid, mannitol and cholesterol have a profound effect on vesicle size and entrapment efficiency. FTIR studies concluded that there is no interaction between drug and excipients. Rheological studies of all gels prepared with 1%, 2% and 3%w/w carbopol gave clear idea of concentration of carbopol (1%) is require for preparation of stable gel formulation. In-vitro studies of gels encapsulating anti-diabetic drugs were found to increase the skin permeation and deposition showing a sustain effect when compared to marketed gel (conventional gel). Stability studies performed for optimized gel formulation indicate that prepared gels have more stability at freezing temperature than that room temperature, suggesting the storage at low temperatures

Keywords: Naproxen, proliposomal gel, HPMC K15M, PEG, Carbopol.