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Abstract

FORMULATION & EVALUATION OF LAMOTRIGINE NANOSUSPENSION WITH STUDY OF CRITICAL QUALITY ATTRIBUTES (CQA)

*Neel Sawant, Yagnesh Modi, Aerik Tailor, Priyanka Mohite, Neelam Sharma, Dr. Chainesh Shah and Dr. Umesh Upadhyay

Abstract

Solubility of a drug can be a limiting factor for its formulation into a suitable dosage form & it influences the effectiveness of a drug to a large extent. Nanosuspensions are defined as the sub-micron colloidal dispersions of pure drug particles stabilized by surfactants. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features & unique advantages. Lamotrigine Nanosuspension was prepared using emulsification-solvent diffusion method with overcoming limiting factor. All the formulations were subjected to invitro evaluation & the statistically optimized one was used for stability, scanning electron microscopic & differential scanning calorimetric studies. By virtue of the submicron particle size & distinct physicochemical properties, nanosuspension has the potential ability to tackle many formulation & drug delivery issues typically associated with poorly water & lipid soluble drugs. Lamotrigine undergoes extensive hepatic metabolism upon oral administration & its absorption is affected in the presence of food. This study was aimed to develop nanosuspension of Lamotrigine & investigate its formulation characteristics. The application of nanosuspensions in different drug delivery systems such as oral, ocular, brain, topical, buccal, nasal & transdermal routes are currently undergoing extensive research.

Keywords: Lamotrigine, Nanosuspension, QBD, Epilepsy, CQA, Technology Advancement.


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