Abstract

REVIEW ON RESEALED ERYTHROCYTES

Naga Sai Prameel*, D. Eswar Tony, A. Nrendra Babu, R. Naveen, B. Padmavathi and K. Kiranmai

Abstract

Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Leucocytes, platelets, erythrocytes, nanoerythrocytes, hepatocytes, and fibroblasts etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. Erythrocytes are the most abundant cells in the human body (~5.4 million cells/mm3 blood in a healthy male and ~ 4.8 million cells/mm3 blood in a healthy female) having potential carrier capabilities for the delivery of drugs and drug loaded microspheres. Drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers. Encouraging the use of erythrocytes in drug delivery include various advantages like as remarkable degree of biocompatibility, Complete biodegradability, lack of toxic product, controllable life-span, decreasing drug side effects etc. So many drugs like aspirin, steroid, cancer drug which having many side effects are reduce by resealed erythrocyte. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. Current review highlights isolation, drug loading methods, Evaluation methods and applications of resealed erythrocytes for drug delivery.

Keywords: Resealed Erythrocytes, carrier, Isolation, evaluation, Applications of Resealed erythrocytes.