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Abstract

FORMULATION AND EVALUATION OF PRONIOSOMAL GEL OF AMOROLFINE HYDROCHLORIDE

Jayadev N. Hiremath*, Parkash G. Yaragatti, Nagond Mukund M. and Avinash S.G.

Abstract

The aim of this work was to formulate and evaluate antifungal Proniosomal gel containing Amorolfine Hydrochloride. Proniosomes were prepared by coacervation phase separation method using nonionic surfactant (span 60), cholesterol, soya lecithin and other ingredients at different concentrations. All the proniosomal gel formulations were converted to niosomal suspensions and evaluated for entrapment efficiency, reproducibility, spontaneity, vesicular diameter, shape and size distribution, microphotography, FTIR studies and in vitro drug release. The results suggested that increasing the cholesterol concentration from 10% to 30% in the formulations increases the entrapment efficiency. In formulations with lecithin, entrapment efficiency decreased with increase in its concentration. The sizes of proniosomes were found to be uniform and spherical in shape. The IR spectral analysis suggested that there was no interaction between the drug and formulation additives. The kinetic parameters were studied using dissolution software PCP DISSOV.2. Proniosomal gel with 30% of cholesterol/lecithin formulations provided better controlled release over period of 15 hrs.

Keywords: Proniosomal gels, Amorolfine Hydrochloride, Cholesterol, Lecithin and Span 60.


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