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Abstract

STUDY OF ANTIOXIDANT EFFICACY OF ABELMOCHUS ESCULENTUS (OKRA) FRUITS’ VARIETIES ON RATS FED HIGHFAT DIET

DH Mhya*, AA Nuhu, A. Mohammed, SI. Yau, MA. Milala, MK. Atiku and AM. Wudil

Abstract

Consumption of diet rich in fats have been reported to promotes the progression of oxidative stress. Literature survey shows that Okra fruits has the potentials to ameliorate oxidative stress. However, Okra plants are of different varieties, and whether their antioxidant efficacies may vary with varieties is not known. This has prompted the study to compare antioxidant activities of two varieties of Okra fruits (NHBAI- B and Yar Kolon) that showed potent antihyperlidemic and rich phytochemicals content as reported by the authors’ previous study. NHB-AI-B and Yar Kolon okra fruits were sliced, air dried and pulverized then extracted with methanol (80%) using Soxhlet extractor and concentrated at 30∘C in a rotary evaporator then air dried. Nine groups of five rats were fed high-fat diet for 35 days followed by treatment with extracts for 21 days. Groups 1-3 (rats received varied dose of NHB-AI-B okra fruit variety), group 4-6 (rats received varied dose of Yar kolon okra fruit variety), group 7 (positive control), group 8: (normal control), and group 9 (negative control). Oxidative stress markers were assayed from serum of each rat. The results showed an elevated malondialdehyde (MDA) levels with low activities of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) in rats fed high-fat diet. Treatment with extracts of the okra fruits varieties lowered MDA levels and promotes SOD, CAT, GSH activities in the rats’ groups. In conclusion, findings from the study suggested both NHB-AI-B and Yar Kolon fruits varieties exert antioxidant activities likely to be in a similar manner.

Keywords: Okra, varieties, NHB-AI-B, Yar Kolon, fruit-extracts, antioxidant, rats, high-fat diet.


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