Abstract

A REVIEW: FORMULATION OF LORNOXICAM LOADED SOLID SELF MICRO-EMULSIFYING DRUG DELIVERY SYSTEM

Harshada Wagh*, Dr. Pankaj Chaudhari, Anup Akarte, Kalpesh Wagh and Dr. P. H. Patil

Abstract

The present work was to improve a solid self-emulsifying drug delivery system (SEDDS) for oral poorly water-soluble drug lornoxicam. The liquid (SEDDS) consisted of capmul MCM as oil phase, tween 20 as surfactant and PEG 400 as co-surfactant. Oil, surfactant and co-surfactant were selected on the basis of solubilisation capacity of drug and emulsification ability of surfactant and cosurfactants. The formulations were optimized by constructing the pseudo-ternary phase diagram. The liquid formulation was solidified by laboratory scale spray dryer, using Aerosil 200 as solid carrier. The solid SEDDS shows greater drug release thus, solid SEDDS improves the oral bioavailability and may provide the useful solid dosage form for oral poorly water soluble drugs.

Keywords: Lornoxicam, Self emulsifying drug delivery system, Bioavailability, Solidcarrier, Capmul MCM, Tween 20, PEG 400.