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Abstract

A REVIEW ON VARIOUS ANALYTICAL METHODS DEVELOPED AND VALDATED FOR ESTIMATION OF ATORVASTATIN CALCIUM AND EZETIMIBE

Harsh Bhandari*, Dr. Jasmina Surati, Sagarkumar Patel, Dr. Ashok Akbari, Dr. Dhiren Shah and Nidhi Patel

Abstract

Atorvastatin calcium is an HMG-CoA reductase inhibitor and Ezetimibe is a cholesterol inhibitor. Atorvastatin calcium is used to lower the LDL and triglycerides level. It also lower the chances of heart attack and stroke. Ezetimibe is used to reduce the hyperlipidemia, alone or in combination with other cholesterol lowering agents. The combination is used together with proper diet to treat high cholesterol and triglycerides levels in the blood. The combination was approved by US-FDA in May 2013 under the trade name Liptruzet, Atozet. A survey of literature and review published in various analytical and pharmaceutical journals has been conducted and the methods which were developed and used for determination as single and combination in bulk drugs, in pharmaceutical formulation, and in biological fluids have been reviewed. This review covers the analytical methods including spectrophotometric methods, chromatographic methods including HPLC, RP-HPLC and HPTLC, liquid chromatography tandem mass spectroscopy were reported.

Keywords: Atorvastatin calcium, Ezetimibe, Hyperlipidemia, HPLC, UV, Liptruzet.


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