Abstract

A PROSPECTIVE STUDY ON PRESCRIPTION PATTERN AND DRUG INTERACTION OF ANTIHYPERTENSIVE DRUGS ON TERTIARY CARE TEACHING HOSPITAL

Dr. Akash Subedi*, Dr. Bipul Subedi and Dr. Allam Pratyusha

Abstract

Introduction: Irrationality while prescribing of drugs are mostly practised globally which leads in higher morbidity and mortality rate hence study of prescription pattern helps to overcome this problem. Objective: To study prescription pattern of antihypertensive drugs in hypertensive patients, to assess the drug interaction in prescription of hypertensive patients and to assess the rationality. Methods and Methodology: Prospective study was conducted in the tertiary care hospital for the period of 6 months. Rationality on 150 antihypertensive prescriptions were analysed using JNC 8 guidelines. Drug interactions (Major) were also accessed. Results: 150 HTN cases were examined among which 45.33% of patients had HTN with DM, 34.67% patients had HTN with other. 36.67% were treated with mono-therapy and 63.33% with combination therapy. Amlodipine, telmisartan, metoprolol are major drug having 25.46%, 14.55%, 20% using rate respectively. 82.67% of prescriptions were rational while 17.33% were irrational according to JNC VIII guidelines and 25.33% of prescriptions have interaction while 74.67% prescriptions were without drug interaction. Conclusion: A 17.33% deviation from guidelines was observed in the treatment and reported to the study department and suggestions were given. 25.33% prescription had DI.

Keywords: Prevalence, treatment, Adherence, DI.