Abstract

FORMULATION AND EVALUATION OF AN ANTI-OXIDANT PRODUCT FROM BETEL LEAF EXTRACT

Kazi Kazeema N., Borana Pravin H.* and Ikale Vijay H.

Abstract

Antioxidants are compounds that inhibit oxidation. Oxidation is a chemical reaction that can produce free radicals, thereby leading to chain reactions that may damage the cells of organisms. Antioxidants provide protection against Reactive Oxygen Species (ROS) i.e. free radicals contributing to cellular aging, atypical pigmentation, mutagenesis, carcinogenesis. Piper betel leaves are a rich source of such natural bioactive compounds namely antioxidants. The use of natural antioxidants is of growing interest, especially in food science and complementary medicines, because some synthetic antioxidants are harmful to human health. The antioxidant activity of P. betel is previously researched by many researchers, and also a work on the formulation of antioxidant cream is done. Considering the following researches into consideration this study is focused on the formulation and evaluation of an antioxidant peeloff mask comprising the ethanolic leaves extract of P. betel. The in-vitro free radical scavenging activity was studied by using Hydrogen Peroxide (H2O2) solution. The ethanolic leaves extract possesses remarkable antioxidant properties which are observed at increasing concentrations. The formulation comprises 2% of ethanolic extract and was formulated by the addition of six different phases using Polyvinyl alcohol (PVP) as a film former. The formulation was subjected to standard evaluation process on parameters like physical evaluation, pH, peel test, thickness measurement, thermodynamic stability study, stability testing, and hydrogen peroxide radical scavenging activity assay. The evaluation of formulated peel-off masks showed satisfactory results and can be a potential cosmetic product when worked on further. Further studies can be conducted on the enhancement of the parameters to market an effective, stable and cost-effective cosmetic product on a large scale.

Keywords: Piper betel, Desipaan, hydrogen peroxide radical scavenging test, antioxidant peel-off mask, cosmetic product.