Abstract

HERBAL LIPOSOMES WITH EFFECTIVENESS AGAINST DIABETES

Rajat Singh, Shivam, Avadh Biharee, Deepak Tomar, Pankaj Kumar, Dheeraj Dubey*

Abstract

The main motive behind this study was to formulate an herbal drug loaded nanosized carrier which enhances the permeability of a hydrophilic herbal drug through the membrane and increases the drug concentration into the systemic circulation. And second motive is to provide a cheap formulation to the future consumers which will be deal with the diabetes on that time. An alternative of that drug was silver nanoparticles present but they are very costly at that time. The effectiveness of the formulation was considered on the basis of the In- Vitro inhibition study of the alpha-amylase by Pterocarpus marsupium loaded liposomes and compared with a positive control acarbose and it was shows that high concentration of drug was as effective as acarbose to inhibit the alpha – amylase. In the end of the study animal testing was done which shows effectiveness of the formulation as compared to the plane and uncovered Pterocarpus marsupium.

Keywords: Liposomes, diabetes, Pterocarpus marsupium, Alloxan.