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Abstract

SAFETY EVALUATION OF SILVER NANOPARTICLES FOR DERMAL APPLICATION

Swati Gajbhiye* and Satish Sakharwade

Abstract

Silver nanoparticles (AgNPs) are an important class of nanomaterials used as new potent antimicrobial agents for a wide range of medical, Cosmetic, hygienic Products. However, toxicity of AgNPs and impact of their physicochemical characteristics in in- vitro and in- vivo models still need to be comprehensively characterized. The aim of this study was to investigate the Cytotoxicity and Toxicity effect of prepared silver nanoparticles in-vitro and in-vivo models. The invitro cytotoxic effect of biologically synthesized silver nanoparticles against L929 cell lines was assessed by the MTT colorimetric technique. For toxicological evaluation Rats were exposed to two concentration 1% and 3% Silver Nanoparticle ointment following OECD guideline 402 for acute dermal toxicity And Sub-Acute Dermal Toxicity of 3% Silver Nanoparticle ointment was evaluated following OECD guideline 410 in rats and results were analyzed by Pathozyme Blood Chemistry analyzer and histopathology was performed on Liver, Kidney, and skin for sub-acute toxicity. Silver nanoparticles exerted no significant cytotoxic effect toward normal cells L929 even at the highest concentration. There was no mortality during the course of experimentation for acute dermal toxicity and in the Sub Acute Dermal Toxicity Study, no mortality in rats were observed and showed no clinical signs of intoxication after application till the end of the study and no gross abnormalities in any organs were observed in all the group animals and showed normal histopathology. Hence, the silver nanoparticles were found to be safe for dermal application in minimal dose.

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