Abstract

EVALUATION OF THE EFFECT OF ADMINISTRATION OF ETHANOL EXTRACTS OF ANDROGRAPHIS PANICULATA LEAVE AND ZINGIBER OFFICINALE RHIZOIDS ON SERUM LIPID PROFILE IN NORMAL WISTAR RATS.

*Essien N. E., Nyah N. U., Bobson P. M. and Tom E. J.

Abstract

The effect of ethanol extracts of Andrographis paniculata leaves and Zingiber officinale rhizoids on serum lipid profile on albino wistar rats was determined. Twenty-five (25) animals weighing 113-233g were randomly assigned five groups of five animals each and one of the groups was randomly chosen to serves as control. Group 1, 2, 3 and 4 (treated groups) were respectively treated with 100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg of combined extracts of the two plants at 50:50 dosage ratio for 3 weeks. Both control and treatment groups of animals were fed with commercial rat mash and with distilled water. The result revealed that there was no significant difference in the mean serum Triglycerol (TG), Total Cholesterol (TC), Low Density Lipoprotein (LDL and Very Low Density Lipoprotein (VLDL) in the treatment groups respectively when compared with the control (p < 0.05). but a significant increase was recorded in the mean serum High Density Lipoprotein (HDL) in the treatment group 2 when compared with group 1 (p > 0.05). The implications of this result was discussed.

Keywords: Andrographis paniculata, Zingiber officinale, Albino wistar rats, Lipid Profile, Ethanol Extract.