Abstract

PATTERN OF PROSTATIC LESIONS A HISTOPATHOLOGICAL STUDY WITH CLINICAL CORRELATION IN A SAMPLE IN IRAQI MALE PATIENTS

Prof. Alaa Ghani Hussain MBChB. FICMS.* and Hiba Khalid MBChB

Abstract

Background: prostatic lesions are a common problem in elderly male that cause significant morbidity and mortality in this age group, histopathological evaluation is a crucial method to reach final diagnosis and treatment. Gleason's grading system is an essential prognostic parameter in adenocarcinoma. Objective: To study the frequency of histopathological types of different lesions of prostate in relation to age and clinical variables, and to analyze adenocarcinoma according to Gleason grading system. Method: This is a retrospective study of 145 randomly selected cases of prostate gland pathology reported from January 2018 to December 2021 at department of pathology, Baghdad Medical City, Al-Emamain Al-Kadhmain Medical city. Result: Most of the lesions were benign (82%), followed by malignant (23%) and prostatic intraepithelial lesions (PIN) formed (2%), the majority of prostatic lesions was in age group (61-70) years. TURP was the most common procedure of prostatic biopsy (54%). The most common was benign prostatic hyperplasia which formed (59.3%) followed by benign prostatic hyperplasia & chronic prostatitis (17.9%) of cases. In adenocarcinoma the highest percentage was of Gleason's score 7 formed (47.8%), followed by score 6 formed (21.7%). Perineural invasion was identified in 65.2% of malignant cases. Conclusion: nodular hyperplasia was the predominant. Prostatic pathology are common in the age group of 61-70 years. TURP specimens were the most common biopsy procedure.in adenocarcinoma cases the most common Gleason's score was 7 and the most common Gleason's grade group was 3. Perineural invasion was identified with high percentage of adenocarcinoma cases.

Keywords: Prostate, Prostatic lesions, Gleason's system, benign prostatic hyperplysia.