Abstract

PHOSPHODIESTERASE FAMILY: CHARACTERIZATION & PROPERTIES

Ajay Kharche* and Dr. Vikas Jain

Abstract

Phosphodiesterases are enzymes which are uniformly distributed in mammalian tissues, play a unique role in cell signalling by hydrolysis of cAMP and cGMP. The PDE family is divided into 11 sub families (PDE 1 to PDE 11). PDE 1 to PDE 6 are well known Phosphodiesterases enzymes because of there presence in various tissues and cells. The main concern is about PDE 7 to PDE 11 as their role is not specified yet. More research is going on to these later families. This review brings together knowledge on overview, distribution, regulation and inhibitors of all PDEs.

Keywords: Phosphodiesterases, Phosphodiesterase inhibitors, PDEs.