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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF CYCLIZINE HYDROCHLORIDE ORODISPERSIBLE TABLET USING NEW GENERATION EXCIPIENT

Swati S. Rawat* and Amol A. Ban

Abstract

Current study attained the successful, cost effective formulation of orodispersible tablet of Cyclizine HCl, histamine blocker used as antimotion sickness or anti-emetic drug, which improves the patient‟s compliance and also provides faster and better drug release, thereby improving the bioavailability of drug as compared to the conventional formulation effecting cost. Comparison of evaluation data of tablets prepared by using new generation excipients and by using plain crospovidone revealed that use of new generation excipient gives better results with low cost. It was concluded that orodispersible tablet of Cyclizine HCl can be successfully prepared by using Ludiflash granules and plain crospovidone. New generation excipient, Ludiflash granules, was found to be superior to that of regular excipient, plain crospovidone. Cyclizine HCl was mixed with new generation excipient (50% to 65%) and regular conventional excipient crosspovidone (2% to 5%) and then compressed into tablets by direct compression method. The prepared tablets were evaluated for various pharmaceutical characteristics such as hardness, friability, weight variation, thickness, disintegration time, drug content, and in vitro drug release. All the formulated tablets were within the acceptable limits. Among the tablet formulations, formula P5 containing 5.5mg of crosspovidone and 90 mg of drug along with other regular excipient showed short disintegration time of almost 34 sec and about 89.41% of drug release after 20 minutes which was much higher than those tablets prepared with 120 mg ludiflash and 50 mg of drug (L5) having disintegration time of almost 24 sec and about 97.54 % of drug release after 20 minutes.

Keywords: CyclizineHCl, orodispersible, crospovidone, Ludiflash, new generation excipient.


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