Abstract

FORMULATION AND EVALUATION OF PARACETAMOL EFFERVESCENT TABLET

Apeksha B. Korde*, Suvarna N. Waghmare, Sujata S. Bote, Rohini S. Palekar and Priti B. Ghumre

Abstract

The oral dosage forms are the furthermost widespread way of taking medicine despite having around drawbacks like slow absorption and thus onset of action is delay. This can be overcome by administrating the medication in liquid from but, many APIs consume limited level of constancy in liquid form. So, Effervescent Tablets turns as an alternate dosage form. The tablet is added into a glass of liquid just previously administration and the medication solution or dispersion is to be drunk instantly. The tablet is rapidly broken separately by internal release of CO2 in water due to interface between tartaric acid and citric acid with alkali metal carbonates or hydrogen carbonate in existence of water. Due to release of CO2 gas, the dissolution of API in water in addition to taste masking effect is enhanced. The advantages of effervescent tablets associated with further oral dosage forms contains an prospect For formulator to expand taste, a added gentle action on patient’s stomach and marketing characteristics. In present work an attempt has been made to formulate an effervescent tablet containing instant release of paracetamol by means of various acids and bases. In present work we are used different acids and bases in dissimilar concentration. In the preformulation study, compatibility evaluation was performed which implies that drug; acids, bases and other excipient are well-matched with each other. The formulation of tablets was done by using wet granulation technique. Then formulated tablets were evaluated for hardness, friability, weight variation, disintegration time and in-vitro drug release. From study it was concluded that F3 shows the better result than the F1 & F2.

Keywords: Effervescent tablet, sustained release, wet granulation method.