Abstract

FREQUENCY OF DERANGED LFT IN PATIENTS WITH FALCIPARUM MALARIA, AT BOLAN MEDICAL COLLEGE AND TEACHING HOSPITALS

*Dr. Abdul Malik Yasinzai, Dr. Qaiser Iqbal, Dr. Muhammad Umar Marri, Dr. Huma Naeem Tareen, Dr. Maqbool Ahmed, Dr. Mohammad Usman and Mir Zaman Kasi

Abstract

Introduction: According to world health organization (WHO) there has been increasing number of reports of malarial hepatopathy, from Asian countries. The majority of the cases have either isolated infection with P. falciparum or a mixed infection with both P. falciparum and P. vivax. So this study will provides us the latest and updated information regarding frequency of deranged LFT in patients with falciparum malaria. Objective: To determine frequency of deranged LFT in patients with falciparum malaria. Setting and place of study: Bolan Medical College and Teaching Hospital, Quetta. Cross sectional from 13/2/2017 to 13/2/2018. Materials And Methods: In this study a total of 155 patients were observed. Management was done as per standard guidelines with Quinine Sulphate (IV/Oral) 20 mg/kg body weight stat dose followed by 10 mg/kg body weight in three divided doses for seven days. Outcome variable i.e. derangement in LFTs was assessed as operational definition. Results: mean age was 33 years ± 13.18. Fifty six percent patients were male while 44% patients were female. More over 12% patients had derangement in LFT while 88% patients didn’t had derangement in LFT. Conclusion: Our study concludes that the frequency of deranged LFT was 12% in patients with falciparum malaria.

Keywords: deranged LFT, falciparum malaria, Quinine Sulphate.