Abstract

CO ENZYME Q10 –AN ADJUNCTIVE IN THE PERIODONTAL MANAGEMENT OF TYPE II DIABETIC PATIENTS

*Dr. Joseph Kishore Reddy, Dr. Darshan B. M., Dr. Suchetha A., Dr. Sapna N., Dr. Apoorva S. M., Dr. Divya Bhat

Abstract

Aim: The term diabetes mellitus (DM) describes a metabolic disorder characterized by chronic hyperglycemia with disturbances in the carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or group of microorganisms resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation, recession or both. Periodontitis is stated to be the sixth complication of diabetes. Prevalence of periodontitis in diabetic patients is higher as compared to non-diabetic patients. When periodontitis occurs, reactive oxygen species, which are overproduced mostly by hyperactive neutrophils, could not be balanced by antioxidant defense system and cause tissues damage especially in case of systemic diseases. Coenzyme Q10 functions as an intercellular antioxidant by acting as a primary scavenger of FRs and ROS. The purpose of the study was to evaluate the effect of Co Q10 in patients with chronic periodontitis with and without type 2 diabetes mellitus. Materials and Methods: 60 patients were included in the study and divided into three groups. Group I comprises of chronic periodontitis (CP) without any systemic diseases. Group II comprises of CP with type II diabetes mellitus(DM) with HbA1c less than 7%.Group III comprises of CP with type II DM with HbA1c greater than 7%. All the groups were received SRP along with Coenzyme Q10 at baseline, after 3,6,9 weeks. Clinical parameters like plaque index (PI), Gingival index (GI), Probing pocket depth (PPD), Clinical attachment level (CAL) were recorded at baseline, after 3, 6, 9 weeks. Results: Results showed that there was a statistically significant reduction in the mean PI, GI scores during the study in all the three groups compared with baseline values. There was statistically significant reduction in PPD and CAL in all the three groups compared to baseline values. There was statistically significant difference seen in group I and II in comparison to group III in terms of PPD and CAL. There was no statistically significant difference seen at baseline3 weeks, 6 weeks, 9 weeks values in Group I and II regarding PD and CAL. Conclusion: The topical application of coenzyme Q10 in periodontitis patients has shown improvement in GI, PI, and reduction in pocket depth and gain attachment level. In patients with periodontitis, oral hygiene combined with therapy using CoQ10 could provide improved clinical parameters and long term benefits. But application of antioxidant could not overcome the TOS in group III patients with chronic periodontitis and uncontrolled type II DM.

Keywords: Chronic periodontitis(CP), Diabetes mellitus(DM), CoenzymeQ10(Co Q10). Total oxidative stress(TOS).