WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

TOXICITY AND SEDATION EFFECT OF LAWSONIA INERMIS L

*B. Meddah1, S. Ahid2, M. Ait El Cad1i, M. Ansar3, A. Zellou2, My A. Faouzi1, Y. Cherrah1 and J. Taoufik3

1Research Team pharmacokinetic, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco
2Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco
3Laboratory of therapeutic chemistry, Faculty of Medicine and Pharmacy, Mohammed V Souissi University � Rabat- Morocco.

Abstract

Lawsonia inermis L. is usually use to treat widely pathologies in traditional medicine in Morocco. The aim of this study is to assess the safety effect of the aqueous and ethanolic extract on mice and sedative effect after oral administration. The results showed that acute intra peritoneal administration of extract of seeds and roots were DL50 = 21.06 mg/kg and 88.80 mg/kg respectively whereas the value of DL50 after oral administration of the same extract were 115 mg/kg and 177.70 mg/kg. Leaves extracts was no find with toxicity effect. In addition Lawsonia inermis L. induced sedative effect in animal close to that observed with clobazam. This study confirmed the non toxic effect of extract of leaves of Lawsonia inermis, and showed that roots and seeds extract are toxic. The plant has a sedative effect. This study may explain the rational use of leaves in the traditional medicine.

Keywords: Lawsonia inermis L., extraction, lethal dose 50, acute toxicity, sedation.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More