Abstract

THE EFFECT OF CONCENTRATION TWEEN 80 ON METFORMINE ENCAPSULATED AT CHITOSAN-ALGINATE MATRIX

Dicky Dharmawan and Sari Edi Cahyaningrum*

Abstract

This research purpose to study the effect of concentration tween 80 on metformine encapsulation on chitosan-alginate matrix and investigated some characteristic of metformine after encapsulation process. The encapsulation of metformine performed using chitosan and calcium alginate polymers with tween 80 assurfactant. The concentrations of tween 80 were varieties 0, 1%, 2%, 3%, 4% dan 5% (w/v). The results showed that metformine the highest encapsulation on concentration of tween 80 is 3% (w/v). From the results of the PSA showed 8,5% nano-sized particles and 91,5% microsized particles. Thus, it could be concluded that the addition of surfactant tween 80 could increase the encapsulation efficiency and affected the particle size. Encapsulation resulted have the spectra FTIR vibration on 1679.91 cm-1 that indicated the carboxyl functional group of alginate interaction between with the amine functional group of chitosan.

Keywords: Encapsulation, Metformine, Tween 80.