Abstract

ASSOCIATION OF BONE SPECIFIC ALKALINE PHOSPHATASE WITH CALCIUM HOMEOSTASIS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Shuhub A. Oda, Tarig Ali*, Yahya Y. Z. Farid and Arif. Sami

Abstract

Background: Chronic kidney disease (CKD) is one of the three causes of death that has had the highest increase in the last 20 years, CKD leads to a lot of complications, One of those is a mineral bone disease. bone-specific alkaline phosphatase (BSAP) is the fraction of total alkaline phosphatase that is specific to the osteoblast. Objective: The study aimed to investigate the bone-specific alkaline phosphatase level and to measure parathyroid hormone level in chronic kidney disease. Methodology: A total of 60 patients with chronic kidney disease were studied and 30 individuals who were considered as control. Blood samples were collected from patients and control to assess serum levels of bone alkaline phosphatase, serum levels of parathyroid hormone, and serum levels of (Urea, Creatinine, Ca, and PO4). Results: There is a highly significant difference (P = 0.000) of Serum (Ca, PO4, Creatinine, and urea) concentration. Between control and patient groups, there is a significant difference between BALP and PTH in patients with CKD and dialysis. The result for S. Balp control and patient were 77.83 ± 60.13 and 133.13 ±124.17 respectively, while the result for S. PTH in control and patient were 974.0±569.711994.73±1363.1 respectively with CKD. Conclusion: This study revealed that both S. BALP and S. PTH are significantly affected in patients with chronic kidney disease. Larger studies are required using other clinical diagnostic tools like bone absorption to correlate the clinical and biochemical aspects and the influence of vitamin D and other Biomarker on biochemical parameters also needs to be investigated.

Keywords: Urea, Creatinine, Ca, and PO4.