Abstract

VITAMIN B12 DEFICIENCY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A CROSS SECTIONAL STUDY

Mohammad Usman*, Irfana Hassan, Zahid Saeed, Huma Naeem Tareen, Hazrat Ali and Mir Zaman Kasi

Abstract

Introduction: The diabetes mellitus is a common disease with the prevalence of type-2 diabetes mellitus (T2DM) is 8.3% of the world population and 11.77% of Pakistani population. Metformin is the prototype drug for the management of type 2 diabetes mellitus and may be result into vitamin B12 deficiency with the use in a long time; It inhibits the calcium dependent channels in the last portion of the ileum resulting into malabsorption of vitamin B12. Objective: vitamin B12 deficiency in patients with type 2 diabetes mellitus. Setting & Duration: Medicine OPD, Bolan Medical Complex Hospital/ BMCH Quetta from 16/10/2018 to 16/10/2019. Materials and Methods: This cross sectional study was conducted at Bolan Medical College/hospital Quetta, in the current study a total of 174 patients were observed. Detail history, clinical examination and laboratory investigation was performed for the confirmation of diabetes mellitus. Results: In the current study mean age was 51 years with SD ± 10.59. Forty four percent patients were male while 56% patients were female. Mean duration of diabetes was 15 years with SD ± 11.93. More over 19% patients had vitamin B12 deficiency while 81% patients didn’t have vitamin B12 deficiency. Conclusion: Our study concludes that the frequency of vitamin B12 deficiency was 19% in patients with type 2 diabetes mellitus.

Keywords: Vitamin B12 deficiency, Type II, Diabetes mellitus.