Abstract

MOUTH DISSOLVING FILMS: A REVIEW

Digambar S. Gosavi, Anup M. Akarte*, Pankaj M. Chaudhari, Kalpesh S. Wagh, Prakash H. Patil

Abstract

Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. Many Pharmaceutical companies and academic experts across the world are already in the process of exploring the true potential of these films in delivering drugs not only from synthetic source but also from natural source. The beauty of this unique drug delivery system is that they don’t need water for consumption, as we see with consumption of conventional dosage forms (tablets, capsules), by the subjects. In addition, these delivery systems are excellent in gaining patient compliance in general and particularly the pediatric and geriatric patient population. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved. Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films.

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