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Abstract

FORMULATION & EVALUATION OF FAST DISSOLVING ORAL FILM

Tatwashil Kshirsagar*, Naresh Jaiswal, Gitanjali Chavan, Krushna Zambre, Sawandkar Ramkrushna and Deshmukh Dinesh

Abstract

Mouth dissolving films offers an elegant route for systemic drug delivery. The improved systemic bioavailability results from bypassing first pass effect and better permeability due to a well supplied vascular and lymphatic drainage. Also, large surface areas of absorption, easy ingestion and swallowing, pain avoidance make the oral mucosa a very attractive and selective site for systemic drug delivery. Recent developments in the technology have presented viable dosage alternatives from oral route for wide variety of group of patients. Buccal drug delivery has lately become an important route of drug administration. Various Bioadhesive mucosal dosage forms have been developed. Fastdissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experienced difficulties in swallowing traditional oral solid-dosage forms. The novel technology of oral fastdispersing dosage forms is also known as fast dissolve, rapid dissolve, rapid melt or quick disintegration. However, the function and concept of all these dosage forms are similar. By definition, a solid dosage form that dissolves or disintegrates quickly in the oral cavity, resulting in solution or suspension without the need for the administration of water, is known as an oral fast-dispersing or fast-dissolving dosage form. [Ghodake, P.P.et al., 2013].

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