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Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

DESIGN AND SYNTHESIS OF POTENTIAL ANTITUBERCULAR NOVELS-TRIAZINYL SCAFOLDS CLUBBED WITH 5-(3,4,5- TRIMETOXYPHENYL)-1,3-4-OXADIAZOLE -2-THIOL ENTITY

Jayesh M. Pandya*, Dr. Jyotindra Mahyavanshi, Dr. V. K. Srivastava and Dr. Maharshi Shukla

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Abstract

To affiliate bioactivities in a compact hetero nucleus, two series of striazinyl derivatives clubbed 5-(3,4,5- trimethoxyphenyl)-1,3,4- oxadiazole-2-thiol ring were synthesized and assessed for their efficacy as anti-tubercular agents against tuberculosis H37Rv. The lipophilicity (LogP) influence on the biological profile (MICs) of the prepared products was also discussed. Upon biological screening, it was observed that the majority of the compounds were found to possess a significant broad spectrum antitubercular (6.25e25mg/mL of MIC) potential. The structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR spectroscopy and Elements: al analysis.

Keywords: Cyanuric chloride, 2-mercapto oxadiazole, 3-chloro-4-fluoro aniline, morpholine, antitubercular activity.


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