Abstract

FORMULATION AND EVALUATION OF SUCRALFATE PASTE FOR CHEMOTHERAPY INDUCED ORAL MUCOSITIS

M. F. Farzana Affrin* and Grace Rathnam

Abstract

Oral mucositis is the most common acute side effect experienced by patients undergoing chemotherapy. The present study was aimed at developing sucralfate paste by polymerization method to treat oral mucositis using mucoadhesive polymer for site specific and controlled action in oral mucosa. The formulated formulations were characterized in terms of drug content, viscosity, pH, tube extrudability, spreadability, stability and in vivo evaluation. Oral mucositis was induced in male wistar rats by 5 - Fluorouracil and glacial acetic acid and then the treatment was given by applying the sucralfate paste. All the formulations passed all the above tests. The SP 8 formulation which had higher viscosity, spreadability and tube extrudability was chosen as the best formulation and evaluated for its stability and in vivo efficacy. Assessment of oral mucositis indicates that the SP 8 formulation is safe and more effective in healing oral mucositis with statistically significant (P<0.05).

Keywords: Sucralfate, oral mucositis, mucositis score, polymerization.