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Abstract

ANTIDIABETIC AND ANTIOXIDANT POTENTIALS OF YOYO BITTERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Folasade O. Ajao* and Marcus O. Iyedupe

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Abstract

Background: This study investigated the antidiabetic, anti-dyslipidemic and antioxidant activities of Yoyo bitters in streptozotocin- induced diabetic rats. Materials and Methods: Forty (40) Wistar rats weighing (180-200g) were used and diabetes was induced by single intraperitoneal injection of streptozotocin (50mg/kgbw). The animals were randomly divided into four groups (10rats/group). Group I: control, Group II: untreated diabetic, Group III & IV: diabetic rats treated with 0.5ml of Yoyo bitters and 2mg/kgbw Glimepiride respectively for 4 weeks. Food and water intake were recorded daily, body weight, and blood glucose levels were measured at weekly interval throughout the experiment. On the last day of the experiment, the animals were sacrificed and blood sample were collected for biochemical parameters estimation. Results: Administration of Yoyo bitters significantly (p

Keywords: Yoyo bitters, Diabetes mellitus, Hyperglycemia, Dyslipidemia, Antioxidant.


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