WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

SHORT REVIEW ON GENOTOXIC IMPURITIES IN SARTANS

Amari Mohamed Khamis, Charos Tuychi qizi Omonova and Benson Peter Mugaka*

.

Abstract

The nitrosodimethylamine (NDMA), a confirmed genotoxic impurity, was first reported in valsartan active pharmaceutical ingredient (API) by the European Medicines Agency (EMA) in 2018. Manufacturers performed voluntary recalls followed by investigations of contamination by health regulatory authorities. In this review, we discussed potential sources, mechanism of the formation of NDMA, and other nitrosamines impurities in valsartan, losartan, irbesartan, candesartan, and olmesartan. Additionally, we summarized currently available validated analytical techniques for controlling these impurities as suggested by regulatory authorities. An overview of measurements by regulatory authorities was mentioned, and we also outlined suggestions for viable solutions to avoid future crises.

Keywords: Nitrosamine, ARBs, genotoxic impurities, valsartan recalls.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More