Abstract

PYRAZOLINE DERIVATIVES AND ITS PHARMACOLOGICAL POTENTIAL-REVIEW

Dr. V. M. Mounnissamy and S. Joseva*

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Abstract

Pyrazoline is an important scaffold in the drug discovery process. Various synthetic derivatives of pyrazoline are prepared and evaluated for their various biological activities in a different model. Some analogs of the pyrazoline derivatives are more potent than the corresponding standard drugs. Hence the pyrazoline is considered to be a lead molecule for future drugs. The present review articles discuss the pharmacological activities of pyrazoline derivatives such as Antineoplastic, Antimicrobial, Anti-inflammatory, 5α-reductase inhibitor, Cyclo-oxygenase inhibitor, Anti-malarial, Hypoglycemic and etc.

Keywords: Pyrazoline, Pyrazoline derivatives, Antineoplastic, Antimicrobial, Anti-inflammatory, 5?-reductase inhibitor and antimalarial.