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Abstract

VALIDATED UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF FUROSEMIDE AND AMILORIDE HYDROCHLORIDE IN THEIR COMBINED TABLET DOSAGE FORM

Annmary George* and Dr. Jose Kurien

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Abstract

An accurate, precise, sensitive, spectrophotometric method was developed and validated for simultaneous estimation of Furosemide and Amiloride Hydrochloride in tablet form. The analysis was carried out in JASCO V 560 double beam UV Spectrophotometer. In simultaneous equation method, Furosemide and Amiloride Hydrochloride were quantified using their absorptivity values of at selected wavelengths, 274 nm and 362 nm respectively. Methanol was used as solvent for both drugs. The developed method was validated according to ICH guidelines for evaluation of accuracy, precision, sensitivity etc. The linearity range was found to be 1-11μg/ml for both drugs with correlation coefficient of 0.999 for both drugs. Recovery studies were conducted at three different concentration levels And average percentage in tablet dosage form was determined and found to be 99.58% for Furosemide and 99.61% for Amiloride Hydrochloride. So the developed method permits rapid determination of Furosemide and Amiloride Hydrochloride.

Keywords: Furosemide, Amiloride Hydrochloride, Simultaneous Equation.


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