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Abstract

AN OVERVIEW OF ANALYTICAL METHODS FOR DETERMINING SIMVASTATIN AND EZETIMIBE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Ashwini Thorat*, Shrutika Jagtap, Pragati Sorate, Ashwini Taware and Rajendra Bandal

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Abstract

Ezetimibe is an anticholesteremic drug that binds to the brush border of the small intestine and inhibits cholesterol absorption, resulting in a reduction in cholesterol transport to the liver. Simvastatin is a prodrug in which the lactone ring is hydrolyzed in vivo to produce beta,deltadihydroxy acid, an active metabolite. Simvastatin competes with HMG-COA for HMG-COA reductase after hydrolysis. UV-visible spectroscopy, HPLC (High Performance Liquid Chromatography), and HPLC (High Performance Liquid Chromatography) are the most regularly used methods for determining Simvastatin and Ezetimibe.

Keywords: Simvastatin, Ezetimibe, RP-HPLC, RP-UPLC, HPTLC, UV-spectroscopy, Anticholesteremic.


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